منابع مشابه
Adipose Tissue Dysfunction and Alcoholic Liver Disease
Although much progress has been made over last three decades of research on the mechanisms underlying alcoholic liver disease (ALD), it remains an important health problem in the United States. ALD ranks among the major causes of morbidity and mortality in the world, and affects millions of patients worldwide each year [1]. The disease process is characterized by early steatosis, steatohepatiti...
متن کاملCold-Induced Changes in Gene Expression in Brown Adipose Tissue, White Adipose Tissue and Liver
Cold exposure imposes a metabolic challenge to mammals that is met by a coordinated response in different tissues to prevent hypothermia. This study reports a transcriptomic analysis in brown adipose tissue (BAT), white adipose (WAT) and liver of mice in response to 24 h cold exposure at 8°C. Expression of 1895 genes were significantly (P<0.05) up- or down-regulated more than two fold by cold e...
متن کاملMitochondria Isolated from Rat Brown Adipose Tissue and Liver
Mitochondrial fractions, relatively free from contamination by other cytoplasmic structures, have been isolated by differential centrifugation from homogenates of brown adipose tissue from starved rats. It was possible in such fractions to distinguish two types of mitochondria in this tissue. Type I mitochondria, when morphologically intact, are limited by a bilaminar membrane and show regular ...
متن کاملFatty acid synthesis in liver and adipose tissue.
1. The synthesis of long-chain fatty acids de novo was measured in the liver and in regions of adipose tissue in intact normal and genetically obses mice throughout the daily 24h cycle. 2. The total rate of synthesis, as measured by the rate of incorporation of 3H from 3H2O into fatty acid, was highest during the dark period, in liver and adipose tissue of lean or obese mice. 3. The rate of inc...
متن کاملA subcutaneous adipose tissue–liver signalling axis controls hepatic gluconeogenesis
The search for effective treatments for obesity and its comorbidities is of prime importance. We previously identified IKK-ε and TBK1 as promising therapeutic targets for the treatment of obesity and associated insulin resistance. Here we show that acute inhibition of IKK-ε and TBK1 with amlexanox treatment increases cAMP levels in subcutaneous adipose depots of obese mice, promoting the synthe...
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ژورنال
عنوان ژورنال: Journal of Applied Physiology
سال: 2018
ISSN: 8750-7587,1522-1601
DOI: 10.1152/japplphysiol.00399.2017